ECGenetics Browser

ECG Plotter

Enter a list of SNPs (rs572474770, rs776293589, 2:179698596), a region (2:179381323-179405807) or a Gene (e.g. SCN5A) and click the Go button to extract variants.

RSids, region or gene

rs578347, rs72681760, rs584096, rs12142815, rs776293589, rs115286434, rs4073778, rs113712703, rs12034347, rs553620963, rs1870940, rs4745, rs10908504, rs10797060, rs12143842, rs59852339, rs116381680, rs1763604, rs10918192, rs11580561, rs531706, rs12569204, rs1200130, rs67779898, rs1591734, rs17162854, rs57831591, rs76120745, rs575784488, rs1104859, rs4951365, rs863724, rs35232605, rs568925773, rs340849, rs2503715, rs1532501, rs115282653, 1:225664878_AAGAG_A, rs35937215, rs2298632, rs12117603, rs61775418, rs60965469, rs116015634, rs1707334, rs112288630, rs590041, rs985783, rs34370185, rs2474370, rs846111, rs72677052, rs6702939, rs143221246, rs72845807, rs12257568, rs1977821, rs10787270, rs770537744, rs7918405, rs740746, rs2234962, rs11257655, rs1078806, rs72786007, rs788076, rs12779954, rs211315, rs12777211, rs1733724, rs10740131, rs1037985, 10:73832438_CCT_C, rs2177843, rs6480713, rs80341670, rs1658323, rs1769758, rs3802662, rs117524646, rs10736059, rs117929802, rs11187838, rs10882661, rs11189038, rs671333, rs4935884, rs11220270, rs11221500, rs2625322, rs2074238, rs117236107, rs7118294, rs3729989, rs7479922, 11:60533354_CA_C, rs174536, rs36085849, rs638138, rs777300465, 11:75923599_CA_C, rs10898646, 11:95034279_TA_T, 12:110625059_GTTGTTT_G, rs141066394, rs722726, rs883079, rs61931005, rs188348223, rs11067264, rs7132327, rs142576422, rs373465055, 12:1633920_TGGG_T, rs11062103, rs11609729, rs7307613, rs34219605, rs1051375, rs11049136, 12:31620079_AG_A, rs7315695, rs148885520, rs10849144, 12:51197281_TA_T, rs113671070, 12:57156410_AAAAC_A, rs1149003, rs2769884, rs111403728, rs7317804, rs11616720, rs7993628, 13:49534769_CT_C, rs1965800, rs1886512, rs6571769, rs365990, 14:23929566_AT_A, rs562161427, rs2108706, rs17180489, rs12880339, rs11626401, 14:96872394_AT_A, rs34509141, rs78496852, rs3131560, rs74018128, rs7496259, rs2019185, rs3825977, rs4777245, rs7164883, 15:75187470_CT_C, rs200201338, rs12595786, rs28513927, 15:94705104_GTGTA_G, rs4966020, rs6600238, rs2080512, rs1344533, rs30226, rs3915425, rs12924536, rs12448482, rs4238961, rs735052, rs143721880, rs4784939, rs150728296, rs62044987, rs1045716, rs72791317, rs35559328, rs6565060, 16:88527325_AGGGGC_A, rs4614769, rs12945974, 17:12642266_TTA_T, rs4925095, rs8077048, 17:28267098_CT_C, rs1088450, rs772490616, rs17608766, rs34081637, rs138998340, rs9909004, rs8067476, rs236586, rs312755, rs28360848, rs12051698, rs766320, rs35236676, rs12454640, rs11665344, rs356907, rs476348, rs2848901, rs1126225, rs9952412, rs689049, rs200181073, rs10853935, rs10409940, rs9630873, rs35828463, rs191904180, rs12610825, rs113394178, rs2732861, rs1047392, rs13020178, rs17407658, rs16860332, rs115142950, rs16866397, rs955738, rs11681740, rs6735214, rs7605146, 2:213211032_GC_G, rs907683, rs35394392, rs10165767, rs2595508, rs141501074, rs1368888, rs56036545, rs13026826, rs58470117, rs2121266, rs4671222, rs7609203, rs759664, rs11677371, 2:84085386_AGT_A, rs10193517, rs6730558, rs369307656, rs2025096, rs4811601, rs6084574, rs59499156, rs8115156, rs310614, rs3787112, rs11699612, rs2830965, rs762834393, rs1999323, rs41312993, rs1805128, rs2186370, rs133885, rs72620089, 3:111574251_TCTTC_T, rs1254386, rs142536918, rs7650482, rs1403767, rs4683632, rs4685090, rs11923657, rs11928162, rs13092272, rs759623919, rs6441207, rs55853354, rs4894803, rs545261249, rs375818588, rs1706003, rs760390566, rs55644439, rs6772646, rs62241772, rs41312411, rs572474770, rs571037730, rs76521806, rs6801957, rs11921457, rs1986599, rs113855341, rs62256002, rs6774470, rs332371, rs114564188, rs4677137, rs766206762, rs1906599, rs6533694, rs139446049, rs61760320, rs6846721, 4:155350842_GT_G, rs2292804, rs13127767, rs2062591, rs6824178, rs76383255, rs2333469, rs768695, rs199745043, rs60063444, rs35658696, rs890924, rs335214, 5:132428677_ATT_A, rs1476096, rs11748963, 5:145398089_ACAC_A, rs34289553, rs10054375, rs10076602, rs763696876, rs11745586, rs12652726, rs260399, rs3828591, rs111869282, rs7714577, rs114419215, rs111778721, 5:82594418_CT_C, rs4478445, rs28763977, rs59365541, rs210977, rs663474, rs376054711, rs11153730, rs775204216, rs12212870, rs28581202, 6:122113614_CT_C, rs12209641, rs547691407, rs6940945, rs10457469, rs11961815, rs378273, rs573680085, rs77170649, rs6570952, rs13208950, rs6914036, rs9396858, rs78144291, rs13211463, rs9467373, rs301395, rs772081778, rs61367953, rs3130582, rs9502009, rs730506, rs72825038, rs533119559, rs13245899, rs2520258, rs3128384, rs1997571, 7:116890450_AT_A, rs56216811, rs35680304, rs117104597, rs55851300, rs143016484, rs6461703, 7:35281105_TG_T, rs11764098, rs343057, rs10464373, rs372543528, rs74524365, rs11771799, rs72671655, rs147543128, rs1461990, rs73195040, rs16898508, rs4871397, rs72711245, rs34866937, rs13264524, rs11784619, rs4517166, rs61494024, rs62505473, rs7833518, 8:5828558_GGA_G, rs571690420, rs11776287, rs1562986, rs7820146, rs2445704, rs74552897, rs7866966, rs7030930, rs10980770, rs7850041, rs12001868, 9:33272391_CA_C, rs770250170, rs748802, rs1415221, rs34382015, rs10119967

Search Dataset

Tophits (140k+, fast)

GW (19M+ slow)

PhenoType

Unadjusted

RR-adjusted

Extend region (Kb) in case you provide a single region or gene.

Include the coefficients and 95% CI!

> plot the predicted effect on the means. This is intented to be an illustration, as the effect is exaggerated.

under development, n.verweij@umcg.nl. 2019

(note: Microsoft browsers may not work, try disabling bitdefender)

Download

Colors indicate LD (r2); filled circles indicate the significance of the lead ECG trait; hollow circles indicate the minimum value across ECG all traits.

P-Value treshold:

Please limit to <150 for now, else it will probably fail to plot due to memory issues.

Interactive t-SNE plot (manuscript)

ECG-wide Mendelian randomization

Choose file.

Browse...

Provide a summary statistics file with up to 1000 variants. Include the following columns with headers: CHR, BP, EFAL, NEFAL, EAF, BETA, SE. Ensure positions are on Build 37. This is a try-out. It may be very slow since it needs to query the full 75 GB gz-compressed data and the VPS has no superpowers. Download an example (QT interval) here.

Terms and Data Information

Citation in publications

We request that any use of data obtained from the ECGenetics browser cite the ECG Morphology Paper in Cell Systems 2020: https://doi.org/10.1016/j.cels.2020.08.005. An older version of the manuscript is available on Biorxiv (https://www.biorxiv.org/content/10.1101/648527v1).

Terms of use

All data here are released openly and publicly for the benefit of the wider research community. You can freely download and search the data, and we encourage the use and publication of results generated from these data.

Full summary statistics can be downloaded here: https://dataverse.harvard.edu/dataverse/ecg-genetics/

Contact

✉ n.verweij@umcg.nl (Niek Verweij).